Madonna's brother passed away at the age of 63

Madonna's brother Christopher Ciccone died on October 4 in Michigan at the age of 63 following cancer, the Daily Mail reported.

This is the second death in a matter of weeks for Madonna's family ... Just last month, her stepmother Joan Ciccone died after a battle with what was described as a very aggressive cancer.

Christopher and Madonna were inseparable when her career was just getting started, and he made a name for himself as one of her backup dancers.

He later became Madonna's show designer and backstage manager... and is the art director for Madge's "Blonde Ambition" world tour.

Christopher was also the art director for Madonna's "The Girlie Show" tour ... and has directed music videos for Tony Bennett and Dolly Parton.

Madonna and Christopher, who also enjoyed a career as an interior designer, had a public spat back in 2008 when he slammed her in his biography "Life With My Sister Madonna," which became a New York Times bestseller.

The two eventually reconciled and in 2012 launched their own shoe line. | BGNES