Ukraine said air defences shot down six missiles and 60 attack drones during the second night of the Russian bombing that killed four people, AFP reported.
The overnight raids came a day after the Kremlin launched one of its biggest airstrikes against Ukraine, damaging energy facilities and killing several people.
The Air Force announced that Russia fired a total of 91 projectiles, including 10 missiles and 81 Iranian-designed drones, from several regions in Russia.
"Unfortunately, despite the effective operation of our air defence systems, four people were killed and 16 were injured," President Volodymyr Zelensky said.
He said rescue operations were continuing at the sites of the strikes and vowed to respond to the attacks.
"Crimes against humanity cannot be committed with impunity," Zelensky pointed out.
Air raid sirens echoed throughout the night in the capital Kiev, as well as explosions possibly from air defense systems.
Since the February 2022 invasion, Russia has launched repeated large-scale missile and drone attacks against Ukraine, including punitive strikes on energy facilities.
Local authorities earlier reported that a Russian missile attack on a hotel in Kryvyi Rih, Dnipropetrovsk region killed two people and injured five others.
The attack on the hotel comes just days after a Reuters news agency team was hit by a missile at its hotel in the eastern Ukrainian city of Kramatorsk, killing a security adviser working for the agency. | BGNES